Naturally occurring tertiary amine which competitively antagonises ACh at the muscarinic receptor, causing parasympatholytic effects.
|Class||Naturally occurring tertiary amine. Muscarinic antagonist.|
|Uses||Bradycardia, organophosphate poisoning, antisialogogue|
|Presentation||Clear, colourless solution at 600μg.ml-1. Racemic mixture, with only the L-isomer active|
|Route of Administration||IV|
|Distribution||50% protein bound, VD 3L.kg-1|
|Metabolism||Extensive hepatic hydrolysis|
|Elimination||Renal elimination of metabolites and unchanged drug|
|Resp||Bronchodilation, ↓ secretions|
|CVS||↑ HR due to ↓ AV nodal conduction, peaks within 2-4 minutes and lasts 2-3 hours|
|CNS||Central angicholinergic syndrome, confusion, ↑IOP|
|GIT||↓ LoS tone|
- Smith S, Scarth E, Sasada M. Drugs in Anaesthesia and Intensive Care. 4th Ed. Oxford University Press. 2011.
- Peck TE, Hill SA. Pharmacology for Anaesthesia and Intensive Care. 4th Ed. Cambridge University Press. 2014.