Glycopeptides

Non-β-lactam agents that inhibit cell wall synthesis. They are:

  • Active against gram-positive anerobes and aerobes
  • Bacteriostatic against enterocci and streptococci
  • Bacteriocidal against staphylocci
Property Vancomycin
Uses MRSA, C. difficile
Presentation Powder for reconstitution
Route of Administration PO, IV, Intrathecal
Dosing Peak levels determined by dose, trough levels by dose and interval
Absorption No oral bioavailability. Poor CSF penetration
Distribution VD 4L.kg-1. Poor CSF penetration even with inflammed meninges - higher levels are required for CNS penetration. ~50% protein bound.
Metabolism Minimal hepatic metabolism
Elimination 90% secreted unchanged in urine - significantly prolonged in renal impairment
CVS Phlebitis, red man syndrome (profound non-anaphylactic histamine release with rapid injection)
CNS Ototoxicity
Renal Nephrotoxicity, typically temporary and resolves on cessation
Haematological Thrombocytopenia
Immunological 'Red man syndrome' due to histamine release with rapid injection, with accompanying ↑ HR ↓ BP. Neutropenia.
Other Synergistic action with cephalosporins, aminoglycosides, and rifampicin

References

  1. Peck TE, Hill SA. Pharmacology for Anaesthesia and Intensive Care. 4th Ed. Cambridge University Press. 2014.
  2. Wellington ICU Drug Manual
Last updated 2017-09-17

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