Sotalol

The D-isomer of sotalol is a class III antiarrhythmic, whilst the L-isomer also has class II activity.

Property Action
Class Class III antiarrhythmic
Uses Tachyarrhythmia prophylaxis
Presentation Solution at 10mg.ml-1 and tablets
Isomerism Racemic mixture
Route of Administration PO/IV
Dosing PO: 40-160mg BD IV: 50-100mg over 20 minutes
Absorption >90% bioavailability
Distribution No protein binding
Metabolism Not metabolised
Elimination Excreted unchanged in urine
Resp Bronchospasm
CVS Torsades (< 2%) - more common with high doses, long QT, and electrolyte imbalances
CNS Masking symptoms of hypoglycaemia
GU Sexual dysfunction

References

  1. Peck TE, Hill SA. Pharmacology for Anaesthesia and Intensive Care. 4th Ed. Cambridge University Press. 2014.
Last updated 2017-09-22

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