Sugammadex

Property Sugammadex
Class Gamma cyclodextrin.
Uses Reversal of neuromuscular block induced by rocuronium and vecuronium.
Presentation Clear colourless solution at 100mg.ml-1.
Pharmaceutics Store below 30°C.
Route of Administration IV only.
Dosing 2mg.kg-1 if ToF > 2.
4mg.kg-1 if PTC > 2.
16mg.kg-1 for reversal following RSI dose.
Distribution VD of 11-14L.kg-1.
Metabolism Not metabolised.
Elimination Renal elimination of active drug and complex.
Mechanism of Action Forms a complex with rocuronium and vecuronium, causing reversal of neuromuscular blockade.
CVS Rarely may precipitate bradycardia - can result in cardiac arrest.
Immune Analphylaxis.
Other Interacts with OCP - treat as missed pill
Shortened duration of rocuronium and vecuronium when used within 24 hours of sugammadex administration. Onset is delayed up to 5 minutes, and duration shortened by 10-15 minutes. This period may be extended in renal failure.

References

  1. Sugammadex Full Prescribing Information. FDA.
Last updated 2017-09-22

results matching ""

    No results matching ""