|Uses||Reversal of neuromuscular block induced by rocuronium and vecuronium.|
|Presentation||Clear colourless solution at 100mg.ml-1.|
|Pharmaceutics||Store below 30°C.|
|Route of Administration||IV only.|
|Dosing||2mg.kg-1 if ToF > 2.
4mg.kg-1 if PTC > 2.
16mg.kg-1 for reversal following RSI dose.
|Distribution||VD of 11-14L.kg-1.|
|Elimination||Renal elimination of active drug and complex.|
|Mechanism of Action||Forms a complex with rocuronium and vecuronium, causing reversal of neuromuscular blockade.|
|CVS||Rarely may precipitate bradycardia - can result in cardiac arrest.|
|Other||Interacts with OCP - treat as missed pill
Shortened duration of rocuronium and vecuronium when used within 24 hours of sugammadex administration. Onset is delayed up to 5 minutes, and duration shortened by 10-15 minutes. This period may be extended in renal failure.